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Oxidative C-C Bond Cleavage for the Synthesis of Aryl Carboxylic Acids from Aryl Alkyl Ketones

Liang Xu, Shengpeng Wang, Bajin Chen, Meichao Li*, Xinquan Hu, Baoxiang Hu, Liqun Jin, Nan Sun, Zhenlu Shen*

*Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, P. R. of China, Email: limczjut.edu.cn, zhenlushenzjut.edu.cn

L. Xu, S. Wang, B. Chen, M. Li, X. Hu, B. Hu, L. Jin, N. Sun, Z. Shen, Synlett, 2018, 29, 1505-1509.

DOI: 10.1055/s-0037-1609751 (free Supporting Information)


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Abstract

A metal-free and one-pot two-step synthesis of aryl carboxylic acids from aryl alkyl ketones has been performed with iodine as the catalyst, DMSO and TBHP as the oxidants. Various aryl alkyl ketones could be converted into their corresponding aryl carboxylic acids in very good yields.

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Key Words

aryl alkyl ketones, aryl carboxylic acids, oxidative cleavage, iodine, dimethyl sulfoxide, tert-butyl hydroperoxide


ID: J60-Y2018