Highly Regio- and Stereoselective Catalytic Synthesis of Conjugated Dienes and Polyenes
Vu T. Nguyen, Hang T. Dang, Hoang H. Pham, Viet D. Nguyen, Carsten Flores-Hansen, Hadi D. Arman and Oleg V. Larionov*
*Department of Chemistry, The University of Texas at San
Antonio, San Antonio, Texas 78249, United States, Email:
oleg.larionovutsa.edu
V. T. Nguyen, H. T. Dang, H. H. Pham, V. D. Nguyen, C. Flores-Hansen, H. D. Arman, O. V. Larionov, J. Am. Chem. Soc., 2018, 140, 8434-8438.
DOI: 10.1021/jacs.8b05421
see article for more reactions
Abstract
A regioselective base-induced ring opening of readily available sulfolenes followed by a stereoselective palladium-catalyzed cross-coupling enable a practical and scalable dienylation. The dienylation reaction is particularly useful for the synthesis of synthetically challenging dienes containing cis double bonds and conjugated polyenes.
see article for more examples
Key Words
ID: J48-Y2018