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Transition-Metal-Free Aminoacylation of Ynones with Amides: Synthesis of 3-Carbonyl-4-quinolinones or Functionalized Enaminones

Zhong Zheng, Qihai Tao, Yujuan Ao, Murong Xu and Yanzhong Li*

*Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China, Email:

Z. Zheng, Q. Tao, Y. Ao, M. Xu, Y. Li, Org. Lett., 2018, 20, 3907-3910.

DOI: 10.1021/acs.orglett.8b01492 (free Supporting Information)

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A base-promoted insertion of ynones into the C-N σ-bond of amides enables a transition-metal-free synthesis of substituted quinolin-4(1H)-ones or enaminones. Easily accessible starting materials and high atom economy make this procedure attractive.

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Key Words


ID: J54-Y2018