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OBO-Protected Pyruvates as Reagents for the Synthesis of Functionalized Heteroaromatic Compounds

C. Henrique Alves Esteves, Maria Koyioni, Kirsten E. Christensen, Peter D. Smith and Timothy J. Donohoe*

*Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, U.K., Email: timothy.donohoechem.ox.ac.uk

C. H. A. Esteves, M. Koyioni, K. E. Christensen, P. D. Smith, T. J. Donohoe, Org. Lett., 2018, 20, 4048-4051.

DOI: 10.1021/acs.orglett.8b01614 (free Supporting Information)


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Abstract

Cyclization, aromatization, and OBO deprotection of diketo OBO-protected carboxylates, using two distinct routes, gives access to valuable α-acyl heteroaromatic compounds.

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Pyruvate Enolate Arylation and Alkylation: OBO Ester Protected Pyruvates as Useful Reagents in Organic Synthesis

C. H. A. Esteves, C. J. J. Hall, P. D. Smith, T. J. Donohoe, Org. Lett., 2017, 19, 5248-5251.


Key Words

pyrroles, furans


ID: J54-Y2018