Visible-Light-Mediated Metal-Free Synthesis of Aryl Phosphonates: Synthetic and Mechanistic Investigations
William Lecroq, Pierre Bazille, Fabrice Morlet-Savary, Martin Breugst*, Jacques Lalevée, Annie-Claude Gaumont and Sami Lakhdar*
*Normandie Univ., UNICAEN, CNRS, 6, Boulevard Maréchal Juin,
Caen 14000 France; Department für Chemie, Universität zu Köln, Greinstraße 4,
50939 Köln, Germany, Email: sami.lakhdar
ensicaen.fr, mbreugstuni-koeln.de
W. Lecroq, P. Bazille, F. Morlet-Savary, M. Breugst, J. Lalevée, A.-C. Gaumont, S. Lakhdar, Org. Lett., 2018, 20, 4164-4167.
DOI: 10.1021/acs.orglett.8b01379
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Abstract
The reaction of diaryliodonium salts with phosphites in the presence of a base under visible-light illumination provides a large variety of aryl phosphonates. The reaction proceeds smoothly, tolerates various functionalities, and was applied for the synthesis of pharmaceutically relevant compounds.
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Key Words
phosphonates, photochemistry
ID: J54-Y2018
