Palladium-Catalyzed Reductive Conversion of Acyl Fluorides via Ligand-Controlled Decarbonylation
Yohei Ogiwara*, Yuka Sakurai, Hiroyuki Hattori and Norio Sakai*
*Department of Pure and Applied Chemistry, Faculty of Science and Technology, Tokyo University of Science, Noda, Chiba 278-8510, Japan, Email: yoheiogiwarars.tus.ac.jp, sakachemrs.noda.tus.ac.jp
Y. Ogiwara, Y. Sakuria, H. Hattori, N. Sakai, Org. Lett., 2018, 20, 4164-4167.
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The combination of Pd(OAc)2/Et3SiH enables ligand-controlled non-decarbonylative and decarbonylative conversions of acyl fluorides. When tricyclohexylphosphine (PCy2) was used as the ligand, aldehydes were obtained as simple reductive conversion products, whereas 1,2-bis(dicyclohexylphosphino)ethane (Cy2P(CH2)2PCy2, DCPE) as the ligand favored the formation of hydrocarbons as decarbonylative reduction products.
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