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Merging Visible-Light Photocatalysis and Transition-Metal Catalysis in Three-Component Alkyl-Fluorination of Olefins with a Fluoride Ion

Weili Deng, Weiwei Feng, Yajun Li* and Hongli Bao*

*Fujian Institute of Research on the Structure of Matter, University of Chinese Academy of Sciences, 155 Yangqiao Road West, Fuzhou, Fujian 350002, People's Republic of China, Email: liyajunfjirsm.ac.cn, hlbaofjirsm.ac.cn

W. Deng, W. Feng, Y. Li, H. Bao, Org. Lett., 2018, 20, 4245-4249.

DOI: 10.1021/acs.orglett.8b01658


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Abstract

A light-induced, Ru-catalyzed three-component alkyl-fluorination of olefins under mild reaction conditions provides a wide range of fluorinated products with good functional group tolerance. A key advantage of this photoredox reaction is the use of generic alkyl groups and nucleophilic fluoride.


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Key Words

fluorination, alkylation, multicomponent reactions, photochemistry


ID: J54-Y2018