Vinylogous Blaise Reaction: Conceptually New Synthesis of Pyridin-2-ones
H. Surya Prakash Rao*, Nandurka Muthanna, Ashiq Hussain Padder
*Department of Chemistry, Pondicherry University,
Pondicherry-605 014, India, Email:
hspr.che
pondiuni.edu.in
H. S. P. Rao, N. Muthanna, A. H. Padder, Synlett, 2018, 29, 1649-1653.
DOI: 10.1055/s-0037-1610171
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Abstract
A vinylogous version of the classic Blaise reaction enables a conceptually new synthesis of pyridine rings. A zinc-mediated reaction of (het)aryl or alkyl nitriles with ethyl-4-bromocrotonate provides various C(6)-substituted pyridin-2-ones.
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Key Words
Blaise reaction, 2-pyridones, zinc catalysis, bromoalkenoates
ID: J60-Y2018
