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Diboron-Catalyzed Dehydrative Amidation of Aromatic Carboxylic Acids with Amines

Dinesh N. Sawant , Dattatraya B. Bagal , Saeko Ogawa, Kaliyamoorthy Selvam and Susumu Saito*

*Graduate School of Science, Nagoya University, Chikusa, Nagoya 464-8602, Japan, Email: saito.susumuf.mbox.nagoya-u.ac.jp

D. N. Sawant, D. B. Bagal, S. Ogawa, K. Selvam, S. Saito, Org. Lett., 2018, 20, 4397-4400.

DOI: 10.1021/acs.orglett.8b01480 (free Supporting Information)


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Abstract

Tetrakis(dimethylamido)diboron and tetrahydroxydiboron catalyze a simple and highly efficient condensation of aromatic carboxylic acids with amines to provide aryl amides. This catalytic approach avoids the use of stoichiometric or additional dehydrating agents.

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Key Words

amides


ID: J54-Y2018