Organic Chemistry Portal



Diboron-Catalyzed Dehydrative Amidation of Aromatic Carboxylic Acids with Amines

Dinesh N. Sawant , Dattatraya B. Bagal , Saeko Ogawa, Kaliyamoorthy Selvam and Susumu Saito*

*Graduate School of Science, Nagoya University, Chikusa, Nagoya 464-8602, Japan, Email:

D. N. Sawant, D. B. Bagal, S. Ogawa, K. Selvam, S. Saito, Org. Lett., 2018, 20, 4397-4400.

DOI: 10.1021/acs.orglett.8b01480 (free Supporting Information)

see article for more reactions


Tetrakis(dimethylamido)diboron and tetrahydroxydiboron catalyze a simple and highly efficient condensation of aromatic carboxylic acids with amines to provide aryl amides. This catalytic approach avoids the use of stoichiometric or additional dehydrating agents.

see article for more examples

Key Words


ID: J54-Y2018