Direct Amidation of Carboxylic Acids through an Active α-Acyl Enol Ester Intermediate
Xianjun Xu, Huangdi Feng*, Liliang Huang and Xiaohui Liu*
*College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, 333 Longteng Road, Shanghai, 201620, China, Email: hdfengsues.edu.cn, xhui1113163.com
X. Xu, H. Feng, L. Huang, X. Liu, J. Org. Chem., 2018, 83, 7962-7969.
DOI: 10.1021/acs.joc.8b00819 (free Supporting Information)
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Ynoates as novel coupling reagents enable a highly efficient and simple protocol for the direct amidation of carboxylic acids in very good yields via in situ α-acyl enol ester intermediates formation under mild reaction conditions.
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