Direct Amidation of Carboxylic Acids through an Active α-Acyl Enol Ester Intermediate
Xianjun Xu, Huangdi Feng*, Liliang Huang and Xiaohui Liu*
*College of Chemistry and Chemical Engineering, Shanghai
University of Engineering Science, 333 Longteng Road, Shanghai, 201620, China, Email:
hdfeng
sues.edu.cn, xhui1113163.com
X. Xu, H. Feng, L. Huang, X. Liu, J. Org. Chem., 2018, 83, 7962-7969.
DOI: 10.1021/acs.joc.8b00819
see article for more reactions
Abstract
Ynoates as novel coupling reagents enable a highly efficient and simple protocol for the direct amidation of carboxylic acids in very good yields via in situ α-acyl enol ester intermediates formation under mild reaction conditions.
see article for more examples
Key Words
ID: J42-Y2018
