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Direct Amidation of Carboxylic Acids through an Active α-Acyl Enol Ester Intermediate

Xianjun Xu, Huangdi Feng*, Liliang Huang and Xiaohui Liu*

*College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, 333 Longteng Road, Shanghai, 201620, China, Email:,

X. Xu, H. Feng, L. Huang, X. Liu, J. Org. Chem., 2018, 83, 7962-7969.

DOI: 10.1021/acs.joc.8b00819

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Ynoates as novel coupling reagents enable a highly efficient and simple protocol for the direct amidation of carboxylic acids in very good yields via in situ α-acyl enol ester intermediates formation under mild reaction conditions.

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Key Words


ID: J42-Y2018