Ni-Catalyzed Regioselective Alkylarylation of Vinylarenes via C(sp³)-C(sp³)/C(sp³)-C(sp²) Bond Formation and Mechanistic Studies

Shekhar KC, Roshan K. Dhungana, Bijay Shrestha, Surendra Thapa, Namrata Khanal, Prakash Basnet, Robert W. Lebrun and Ramesh Giri*

*Department of Chemistry & Chemical Biology, The University of New Mexico, Albuquerque, New Mexico 87131, United States, Email: rgiriunm.edu

S. KC, R. K. Dhungana, B. Shrestha, S. Thapa, N. Khanal, P. Basnet, R. W. Lebrun, R. Giri, J. Am. Chem. Soc., 2018, 140, 9801-9805.

DOI: 10.1021/jacs.8b05374

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Abstract

A Ni-catalyzed regioselective alkylarylation of vinylarenes with alkyl halides and arylzinc reagents provides 1,1-diarylalkanes. The reaction proceeds well with primary, secondary and tertiary alkyl halides, and electronically diverse arylzinc reagents.

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Key Words

arylation, alkylation, multicomponent reactions

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ID: J48-Y2018