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Regiospecific Three-Component Aminofluorination of Olefins via Photoredox Catalysis

Jia-Nan Mo, Wan-Lei Yu, Jian-Qiang Chen, Xiu-Qin Hu* and Peng-Fei Xu*

*State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, P. R. China, Email:,

J.-N. Mo, W.-L. Yu, J.-Q. Chen, X.-Q. Hu, P.-F. Xu, Org. Lett., 2018, 20, 4471-4474.

DOI: 10.1021/acs.orglett.8b01760

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In a highly regioselective, direct visible-light-mediated aminofluorination of styrenes, a shelf-stable N-Ts-protected 1-aminopyridine salt serves as the nitrogen-radical precursor, and the commercially available hydrogen fluoride-pyridine was used as the nucleophilic fluoride source.

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Key Words

protected primary amines, sulfonamides, fluorination, multicomponent reactions

ID: J54-Y2018