Base-Mediated Intramolecular Decarboxylative Synthesis of Alkylamines from Alkanoyloxycarbamates
Peihe Li, Nuannuan Ma, Zheng Wang, Qipu Dai* and Changwen Hu*
*School of Chemistry and Chemical Engineering, Beijing
Institute of Technology, Beijing 100081, China, Email: daiqipu
bit.edu.cn,
cwhubit.edu.cn
P. Li, N. Ma, Z. Wang, Q. Dai, C. Hu, J. Org. Chem., 2018, 83, 8233-8240.
DOI: 10.1021/acs.joc.8b00970
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Abstract
An intramolecular decarboxylation of readily prepared alkanoyloxycarbamates enables a general and effective synthesis of primary and secondary alkylamines. The reaction tolerates a broad range of functional groups and the corresponding products were obtained in good yields under mild conditions.
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Key Words
protected primary amines, Boc-protected amines, carbamates
ID: J42-Y2018
