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Base-Mediated Intramolecular Decarboxylative Synthesis of Alkylamines from Alkanoyloxycarbamates

Peihe Li, Nuannuan Ma, Zheng Wang, Qipu Dai* and Changwen Hu*

*School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, China, Email: daiqipubit.edu.cn, cwhubit.edu.cn

P. Li, N. Ma, Z. Wang, Q. Dai, C. Hu, J. Org. Chem., 2018, 83, 8233-8240.

DOI: 10.1021/acs.joc.8b00970 (free Supporting Information)


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Abstract

An intramolecular decarboxylation of readily prepared alkanoyloxycarbamates enables a general and effective synthesis of primary and secondary alkylamines. The reaction tolerates a broad range of functional groups and the corresponding products were obtained in good yields under mild conditions.


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Key Words

protected primary amines, Boc-protected amines, carbamates


ID: J42-Y2018