Iridium-Catalyzed Asymmetric Transfer Hydrogenation of Alkynyl Ketones Using Sodium Formate and Ethanol as Hydrogen Sources
Yang-Ming Zhang, Ming-Lei Yuan, Wei-Peng Liu, Jian-Hua Xie* and Qi-Lin Zhou
*State Key Laboratory and Institute of Elemento-organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China, Email: jhxienankai.edu.cn
Y.-M. Zhang, M.-L. Yuan, W.-P. Liu, J.-H. Xie, Q.-L. Zhou, Org. Lett., 2018, 20, 4486-4489.
DOI: 10.1021/acs.orglett.8b01787 (free Supporting Information)
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In the presence of sodium formate and ethanol as hydrogen sources, a series of alkynyl ketones were hydrogenated by a chiral spiro iridium catalyst to provide propargylic alcohols with high enantiomeric excess.
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