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Iridium-Catalyzed Asymmetric Transfer Hydrogenation of Alkynyl Ketones Using Sodium Formate and Ethanol as Hydrogen Sources

Yang-Ming Zhang, Ming-Lei Yuan, Wei-Peng Liu, Jian-Hua Xie* and Qi-Lin Zhou

*State Key Laboratory and Institute of Elemento-organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China, Email: jhxienankai.edu.cn

Y.-M. Zhang, M.-L. Yuan, W.-P. Liu, J.-H. Xie, Q.-L. Zhou, Org. Lett., 2018, 20, 4486-4489.

DOI: 10.1021/acs.orglett.8b01787 (free Supporting Information)


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Abstract

In the presence of sodium formate and ethanol as hydrogen sources, a series of alkynyl ketones were hydrogenated by a chiral spiro iridium catalyst to provide propargylic alcohols with high enantiomeric excess.

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Key Words

reduction of carbonyl compounds, formates


ID: J54-Y2018