Zinc-Mediated Decarboxylative Alkylation of Gem-difluoroalkenes
Liting Yu, Mei-Lin Tang, Chang-Mei Si, Zhi Meng, Yongxi Liang, Jilai Han, Xun Sun*
*Department of Natural Products Chemistry, School of Pharmacy,
Fudan University, Shanghai 201203, China, Email: sunxunf
shmu.edu.cn
L. Yu, M.-L. Tang, C.-M. Si, Z. Meng, Y. Liang, J. Han, X. Sun, Org. Lett., 2018, 20, 4579-4583.
DOI: 10.1021/acs.orglett.8b01866
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Abstract
A mild and efficient zinc-mediated decarboxylative alkylation of gem-difluoroalkenes with N-hydroxyphthalimide (NHP) esters provides Z-monofluoroalkenes in good yields. The reaction tolerates a broad range of functional groups and can be easily scaled up.
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Key Words
vinylation, fluoroalkenes, zinc
ID: J54-Y2018
