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Zinc-Mediated Decarboxylative Alkylation of Gem-difluoroalkenes

Liting Yu, Mei-Lin Tang, Chang-Mei Si, Zhi Meng, Yongxi Liang, Jilai Han, Xun Sun*

*Department of Natural Products Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, China, Email:

L. Yu, M.-L. Tang, C.-M. Si, Z. Meng, Y. Liang, J. Han, X. Sun, Org. Lett., 2018, 20, 4579-4583.

DOI: 10.1021/acs.orglett.8b01866

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A mild and efficient zinc-mediated decarboxylative alkylation of gem-difluoroalkenes with N-hydroxyphthalimide (NHP) esters provides Z-monofluoroalkenes in good yields. The reaction tolerates a broad range of functional groups and can be easily scaled up.

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Key Words

vinylation, fluoroalkenes, zinc

ID: J54-Y2018