Metal-Free Oxidative Decarbonylative [3+2] Annulation of Terminal Alkynes with Tertiary Alkyl Aldehydes toward Cyclopentenes
Hua-Xu Zou, Yang Li*, Xu-Heng Yang, Jiannan Xiang, Jin-Heng Li*
*State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, Changsha 410082, China, Email: liyang8825490126.com, jhli
hnu.edu.cn
H.-X. Zou, Y. Li, X.-H. Yang, J. Xiang, J.-H. Li, J. Org. Chem., 2018, 83, 8581-8588.
DOI: 10.1021/acs.joc.8b01130
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Abstract
A metal-free oxidative decarbonylative [3+2] annulation of terminal alkynes with tertiary γ,δ-unsaturated aldehydes provides cyclopentenes, whereas the reaction of terminal alkynes with 2-methyl-2-arylpropanals provides indenes. The reactions offer broad substrate scope and excellent selectivity.
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Key Words
ID: J42-Y2018