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tert-Butyl Nitrite Promoted Oxidative Intermolecular Sulfonamination of Alkynes to Synthesize Substituted Sulfonyl Pyrroles from the Alkynylamines and Sulfinic Acids

Zhenjie Qi, Yong Jiang, Yanyan Wang, Rulong Yan*

*State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, 730000, Gansu, China, Email:

Z. Qi, Y. Jiang, Y. Wang, R. Yan, J. Org. Chem., 2018, 83, 8607-8614.

DOI: 10.1021/acs.joc.8b00741 (free Supporting Information)

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tert-Butyl nitrite promotes an oxidative metal-free intermolecular sulfonamination of alkynylamines with sulfinic acids to provide substituted sulfonyl pyrroles via tandem addition/cyclization. Various substituted sulfonyl pyrroles are formed in good yields.

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Key Words

tert-Butyl Nitrite, pyrroles

ID: J42-Y2018