Organic Chemistry Portal



Parallel Approaches for the Functionalization of Thietes: α-Metalation versus C-H Activation

Michael Eisold, Adrian Müller-Deku, Felix Reiners, Dorian Didier*

*Department of Chemistry and Pharmacy, Ludwig-Maximilians-University, Butenandtstraße 5-13, 81377 Munich, Germany, Email:

M. Eisold, A. Müller-Deku, F. Reiners, D. Didier, Org. Lett., 2018, 20, 4654-4658.

DOI: 10.1021/acs.orglett.8b01961

see article for more reactions


Two complementary paths enable the synthesis of 3,4-disubstituted thietes in good yields via α-metalation or direct C-H functionalization.

see article for more examples

Methods for the Synthesis of Substituted Azetines

A. N. Baumann, M. Eisold, A. Music, G. Haas, Y. M. Kiw, D. Didier, Org. Lett., 2017, 19, 5681-5684.

One-Pot Preparation of Stable Organoboronate Reagents for the Functionalization of Unsaturated Four- and Five-Membered Carbo- and Heterocycles

A. N. Baumann, M. Eisold, A. Music, D. Didier, Synthesis, 2018, 50, 3149-3160.

Key Words


ID: J54-Y2018