Synthesis of 1,2-Dihydroquinazolines via Rearrangement of Indazolium Salts

Qian Chen*, Zhuqing Mao, Kunqi Gao, Fang Guo, Li Sheng*, Zhonglin Chen*

*School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150080, China, Email: shenglihit.edu.cn, zhonglinchenhit.edu.cn

Q. Chen, Z. Mao, K. Gao, F. Guo, L. Sheng, Z. Chen, J. Org. Chem., 2018, 83, 8750-8758.

DOI: 10.1021/acs.joc.8b01044

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Abstract

A convenient rearrangement of indazolium salts provides 1,2-dihydroquinazolines. The rearrangement passes through cleavage of a N-N bond after basic deprotonation of the 2-benzyl group.

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Key Words

1,2-dihydroquinazolines, benzo-fused N-heterocycles

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ID: J42-Y2018