Organic Chemistry Portal

Abstracts

Search:

Metal-free Reduction of Nitro Aromatics to Amines with B2(OH)4/H2O

Danyi Chen, Yanmei Zhou, Haifeng Zhou*, Sensheng Liu, Qixing Liu, Kaili Zhang, Yasuhiro Uozumi*

*College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang 443002, P. R. of China; Institute for Molecular Science (IMS), Myodaiji, Okazaki 444-8787, Japan, Email: zhouhfctgu.edu.cn, uoims.ac.jp

D. Chen, Y. Zhou, H. Zhou, S. Liu, Q. Liu, K. Zhang, Y. Uozumi, Synthesis, 2018, 50, 1765-1768.

DOI: 10.1055/s-0037-1610086 (free Supporting Information)


see article for more reactions

Abstract

A metal-free reduction of nitro aromatics is mediated by tetrahydroxydiboron under mild conditions in water as solvent to provide various aromatic amines with good functional group tolerance and in good yields.

see article for more examples



Key Words

tetrahydroxydiboron, reduction of nitro compounds, amines, water, green chemistry


ID: J66-Y2018