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Pd-PEPPSI-IPentAn Promoted Deactivated Amination of Aryl Chlorides with Amines under Aerobic Conditions

Fei-Dong Huang, Chang Xu, Dong-Dong Lu, Dong-Sheng Shen, Tian Li, Feng-Shou Liu*

*School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, Zhongshan, Guangdong 528458, China, Email: fengshou2004126.com

F.-D. Huang, C. Xu, D.-D. Lu, D.-S. Shen, T. Li, F.-S. Liu, J. Org. Chem., 2018, 83, 9144-9155.

DOI: 10.1021/acs.joc.8b01205 (free Supporting Information)


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Abstract

A "bulky-yet-flexible" Pd-PEPPSI-IPentAn complex catalyzes a highly efficient amination of sterically hindered (hetero)aryl chlorides with a variety of aliphatic and aromatic amines. The operationally simple protocol smoothly proceeded under mild conditions without the exclusion of air and moisture to provide the desired products.

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Flexible Steric Bulky Bis(Imino)acenaphthene (BIAN)-Supported N-Heterocyclic Carbene Palladium Precatalysts: Catalytic Application in Buchwald-Hartwig Amination in Air

X.-B. Lan, Y. Li, Y.-F. Li, D.-S. Shen, Z. Ke, F.-S. Liu, J. Org. Chem., 2017, 82, 2914-2925.


Key Words

Buchwald-Hartwig coupling, thiazoles


ID: J42-Y2018