Palladium-Catalyzed Oxidative Three-Component Coupling of Anthranilamides with Isocyanides and Arylboronic Acids: Access to 2,3-Disubstituted Quinazolinones

Chun Qian, Kui Liu, Shou-Wei Tao, Fang-Ling Zhang, Yong-Ming Zhu*, Shi-Lin Yang*

*College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China, Email: zhuyongmingsuda.edu.cn, yangshilinsuda.edu.cn

C. Qian, K. Liu, S.-W. Tao, F.-L. Zhang, Y.-M. Zhu, S.-L. Yang, J. Org. Chem., 2018, 83, 9201-9209.

DOI: 10.1021/acs.joc.8b01218

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Abstract

A palladium-catalyzed oxidative three-component coupling of easily accessible N-substituted anthranilamides with isocyanides and arylboronic acids provides 2,3-disubstituted quinazolinones with a wide substrate scope and good functional group tolerance.

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Key Words

quinazolinones, multicomponent reactions

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ID: J42-Y2018