Catalytic Hydrothiolation: Regio- and Enantioselective Coupling of Thiols and Dienes
Xiao-Hui Yang, Ryan T. Davison, Vy M. Dong*
*Department of Chemistry, University of California, Irvine, California 92697, United States, Email: dongvuci.edu
X.-H. Yang, R. T. Davison, V. M. Dong, J. Am. Chem. Soc., 2018, 140, 10443-10446.
DOI: 10.1021/jacs.8b06957 (free Supporting Information)
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Rh-catalyzed hydrothiolation of 1,3-dienes provides either secondary or tertiary allylic sulfides via selective addition of a thiol to the more substituted double bond. The catalyst tolerates a wide range of functional groups.
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X.-H. Yang, R. T. Davison, S.-Z. Nie, F. A. Cruz, T. M. McGinnis, V. M. Dong, J. Am. Chem. Soc., 2019, 141, 3006-3013.