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Cu(I)-Catalyzed Three-Component Reaction of Diazo Compound with Terminal Alkyne and Nitrosobenzene for the Synthesis of Trifluoromethyl Dihydroisoxazoles

Xinxin Lv, Zhenghui Kang, Dong Xing*, Wenhao Hu*

*School of Chemistry and Molecular Engineering, East China Normal University, 3663 North Zhongshan Road, Shanghai 200062, China, Email:,

X. Lv, Z. Kang, D. Xing, W. Hu, Org. Lett., 2018, 20, 4843-4847.

DOI: 10.1021/acs.orglett.8b01981

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A Cu(I)-catalyzed three-component reaction of terminal alkynes, trifluoromethyl diazo compounds, and nitrosoarenes provides a series of trifluoromethyl-substituted dihydroisoxazoles in high yields under mild reaction conditions.

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Key Words

3-isoxazolines, multicomponent reactions

ID: J54-Y2018