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Co-Catalyzed Synthesis of N-Sulfonylcarboxamides from Carboxylic Acids and Sulfonyl Azides

Yue Fang, Zheng-Yang Gu, Shun-Yi Wang, Jin-Ming Yang*, Shun-Jun Ji*

*Yancheng Teachers University, Yancheng 224051; Soochow University, Suzhou 215123, China, Email: chemyjm163.com, shunjunsuda.edu.cn

Y. Fang, Z.-Y. Gu, S.-Y. Wang, J.-M. Yang, S.-J. Ji, J. Org. Chem., 2018, 83, 9364-9369.

DOI: 10.1021/acs.joc.8b01300 (free Supporting Information)


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Abstract

A Co-catalyzed oxidant-free reaction of carboxylic acids with organic azides in the presence of tert-butyl isocyanide enables an effective synthesis of N-sulfonylcarboxamides in very good yields. The protocol offers short times, low temperatures, and broad substrate scope.

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Key Words

Sulfonamides, Amides


ID: J42-Y2018