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Gold-Catalyzed Hydrohydrazidation of Terminal Alkynes

Dmitry P. Zimin, Dmitry V. Dar'in, Valentin A. Rassadin*, Vadim Yu. Kukushkin*

*Institute of Chemistry, Saint Petersburg State University, Universitetskaya Nab. 7/9, 199034 Saint Petersburg, Russia, Email: v.rassadinspbu.ru, v.kukushkinspbu.ru

D. P. Zimin, D. V. Dar'in, V. A. Rassadin, V. Y. Kukushkin, Org. Lett., 2018, 20, 4880-4884.

DOI: 10.1021/acs.orglett.8b02019 (free Supporting Information)


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Abstract

A facile gold-catalyzed hydrohydrazidation of alkynes with various hydrazides provides a wide range of substituted keto-N-acylhydrazones in very good yields under mild conditions. The reaction exhibits high functional group tolerance, and is insensitive to electronic and steric effects.

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Key Words

hydrazones


ID: J54-Y2018