Gold-Catalyzed Hydrohydrazidation of Terminal Alkynes
Dmitry P. Zimin, Dmitry V. Dar'in, Valentin A. Rassadin*, Vadim Yu. Kukushkin*
*Institute of Chemistry, Saint Petersburg State University, Universitetskaya Nab. 7/9, 199034 Saint Petersburg, Russia, Email: v.rassadinspbu.ru, v.kukushkinspbu.ru
D. P. Zimin, D. V. Dar'in, V. A. Rassadin, V. Y. Kukushkin, Org. Lett., 2018, 20, 4880-4884.
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A facile gold-catalyzed hydrohydrazidation of alkynes with various hydrazides provides a wide range of substituted keto-N-acylhydrazones in very good yields under mild conditions. The reaction exhibits high functional group tolerance, and is insensitive to electronic and steric effects.
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