Organic Chemistry Portal



Gold-Catalyzed Hydrohydrazidation of Terminal Alkynes

Dmitry P. Zimin, Dmitry V. Dar'in, Valentin A. Rassadin*, Vadim Yu. Kukushkin*

*Institute of Chemistry, Saint Petersburg State University, Universitetskaya Nab. 7/9, 199034 Saint Petersburg, Russia, Email:,

D. P. Zimin, D. V. Dar'in, V. A. Rassadin, V. Y. Kukushkin, Org. Lett., 2018, 20, 4880-4884.

DOI: 10.1021/acs.orglett.8b02019

see article for more reactions


A facile gold-catalyzed hydrohydrazidation of alkynes with various hydrazides provides a wide range of substituted keto-N-acylhydrazones in very good yields under mild conditions. The reaction exhibits high functional group tolerance, and is insensitive to electronic and steric effects.

see article for more examples

Key Words


ID: J54-Y2018