Tf2O-Promoted Activating Strategy of Phosphate Analogues: Synthesis of Mixed Phosphates and Phosphinate
Hai Huang, Jeffrey Ash, Jun Yong Kang*
*Department of Chemistry and Biochemistry, University of Nevada Las Vegas, 4505 South Maryland Parkway, Las Vegas, Nevada 89154-4003, United States, Email: junyong.kangunlv.edu
H. Huang, J. Ash, J. Y. Kang, Org. Lett., 2018, 20, 4983-4941.
see article for more reactions
A metal-, toxic chloride reagent-free activating strategy of various phosphates with Tf2O and pyridine enables a facile synthesis of functional phosphates such as alkyl phosphates, aza phosphates, thiophosphate, and mixed diaryl phosphates via a transient phosphorylpyridin-1-ium species.
see article for more examples