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Gold(I)-Catalyzed and H2O-Mediated Carbene Cascade Reaction of Propargyl Diazoacetates: Furan Synthesis and Mechanistic Insights

Ming Bao, Yu Qian, Han Su, Bing Wu, Lihua Qiu, Wenhao Hu*, Xinfang Xu*

*School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China, Email: huwh9mail.sysu.edu.cn, xinfangxusuda.edu.cn

M. Bao, Y. Qian, H. Su, B. Wu, L. Qiu, W. Hu, X. Xu, Org. Lett., 2018, 20, 5332-5335.

DOI: 10.1021/acs.orglett.8b02251 (free Supporting Information)


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Abstract

A gold-catalyzed water-mediated carbene cascade reaction of propargyl diazoacetates provides furan products in good to high yields with broad substrate generality.

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Key Words

furans


ID: J54-Y2018