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Direct Substitution of Secondary and Tertiary Alcohols To Generate Sulfones under Catalyst- and Additive-Free Conditions

Yanan Liu, Peizhong Xie*, Zuolian Sun, Xiangyang Wo, Cuiqing Gao, Weishan Fu, Teck-Peng Loh*

*Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Email:

Y. Liu, P. Xie, Z. Sun, X. Wo, C. Gao, W. Fu, T.-P. Loh, Org. Lett., 2018, 20, 5353-5356.

DOI: 10.1021/acs.orglett.8b02188 (free Supporting Information)

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A catalyst-free, environmentally benign protocol provides propargylic sulfones containing highly congested carbon centers from easily accessible alcohols and sulfinic acids with water as the only byproduct via an in situ dehydrative cross-coupling process.

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Key Words

propargylic sulfones

ID: J54-Y2018