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Phosphine-Free [3+2] Cycloaddition of Propargylamines with Dialkyl Azodicarboxylates: An Efficient Access to Pyrazole Backbone

Yicheng Zhang, Jie Liu*, Xueshun Jia*

*Huaibei Normal University, Huaibei, Anhui 235000; Shanghai University, Shanghai 200444, P. R. of China, Email:,

Y. Zhang, J. Liu, X. Jia, Synthesis, 2018, 50, 3499-3505.

DOI: 10.1055/s-0037-1610168

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A phosphine-free [3+2] cycloaddition reaction of dialkyl azodicarboxylates with substituted propargylamines provides functionalized pyrazoles in good yields and high selectivity at room temperature.

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Key Words

propargylamines, dialkyl azodicarboxylates, cycloaddition, pyrazoles, phosphine-free

ID: J66-Y2018