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Ru-Catalyzed Cross-Dehydrogenative Coupling between Primary Alcohols to Guerbet Alcohol Derivatives: with Relevance for Fragrance Synthesis

Seetharaman Manojveer, Saleh Salahi, Ola F. Wendt, Magnus T. Johnson*

*Centre for Analysis and Synthesis, Department of Chemistry, Lund University, P.O. Box 124, SE-22100 Lund, Sweden, Email:

S. Manojveer, S. Salahi, O. F. Wendt, M. T. Johnson, J. Org. Chem., 2018, 83, 10864-10870.

DOI: 10.1021/acs.joc.8b01558

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RuCl2(PPh3)3 as a precatalyst enables a simple cross dehydrogenative coupling between two different primary alcohols via a borrowing-hydrogen approach. The present methodology is applicable to a large variety of alcohols including long chain aliphatic alcohols and heteroaryl alcohols.

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Key Words

alcohols, benzylation

ID: J42-Y2018