Nickel-Catalyzed Asymmetric Propargylic Amination of Propargylic Carbonates Bearing an Internal Alkyne Group

Kouichi Watanabe, Yusuke Miyazaki, Masataka Okubo, Biao Zhou, Hiroaki Tsuji*, Motoi Kawatsura*

*Department of Chemistry, College of Humanities & Sciences, Nihon University, Sakurajosui, Setagaya-ku, Tokyo 156-8550, Japan, Email: tsujichs.nihon-u.ac.jp, kawatsurchs.nihon-u.ac.jp

K. Watanabe, Y. Miyazaki, M. Okubo, B. Zhou, H. Tsuji, M. Kawatsaru, Org. Lett., 2018, 20, 5448-5451.

DOI: 10.1021/acs.orglett.8b02325

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Abstract

A nickel-catalyzed asymmetric propargylic amination of propargylic carbonates bearing an internal alkyne group with N-methylaniline derivatives provides the corresponding chiral propargylic amines in very good yields with excellent enatioselectivities.

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Key Words

propargylic amines

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ID: J54-Y2018