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Copper-Catalyzed Propargylic Reduction with Diisobutylaluminum Hydride

Yuna Kim, Hanseul Lee, Sunga Park, Yunmi Lee*

*Department of Chemistry, Kwangwoon University, Seoul 01897, Republic of Korea, Email: ymleekw.ac.kr

Y. Kim, H. Lee, H. Lee, Org. Lett., 2018, 20, 5478-5481.

DOI: 10.1021/acs.orglett.8b02413 (free Supporting Information)


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Abstract

A selective copper-catalyzed hydride addition to propargylic chlorides enables a mild and efficient synthesis of allenes from propargylic chlorides in the presence of diisobutylaluminum hydride. This transformation provides a wide range of functionalized allenes in good to excellent yields with high regio- and stereoselectivities.

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Key Words

Allenes, DIBAL-H


ID: J54-Y2018