Copper-Catalyzed Propargylic Reduction with Diisobutylaluminum Hydride
Yuna Kim, Hanseul Lee, Sunga Park, Yunmi Lee*
*Department of Chemistry, Kwangwoon University, Seoul 01897, Republic of Korea,
Email: ymlee
kw.ac.kr
Y. Kim, H. Lee, H. Lee, Org. Lett., 2018, 20, 5478-5481.
DOI: 10.1021/acs.orglett.8b02413
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Abstract
A selective copper-catalyzed hydride addition to propargylic chlorides enables a mild and efficient synthesis of allenes from propargylic chlorides in the presence of diisobutylaluminum hydride. This transformation provides a wide range of functionalized allenes in good to excellent yields with high regio- and stereoselectivities.
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Key Words
ID: J54-Y2018
