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Chloramine Salt Mediated Oxidative Halogenation of Terminal Alkynes with KI or NaBr: Practical Synthesis of 1-Bromoalkynes and 1-Iodoalkynes

Xiaozu Liu, Guojun Chen, Chenglong Li, Peijun Liu*

*Generic Drug Research Center of Guizhou Province, School of Pharmacy, Zunyi Medical University, Zunyi, 563000, P. R. of China, Email: pjliuzmc.edu.cn

X. Liu, G. Chen, C. Li, P. Liu, Synlett, 2018, 29, 2051-2055.

DOI: 10.1055/s-0037-1610259 (free Supporting Information)


Abstract

The use of chloramine-B as the oxidant and KI or NaBr as the halogen source enables a direct oxidative halogenation of terminal alkynes to provide synthetically valuable 1-iodoalkynes and 1-bromoalkynes in very good yields under mild reaction conditions.

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Key Words

oxidative halogenation, 1-bromoalkynes, 1-iodoalkynes, chloramine-B, terminal alkynes


ID: J72-Y2018