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Transition-Metal-Free Esterification of Amides via Selective N-C Cleavage under Mild Conditions

Guangchen Li, Peng Lei, Michal Szostak*

*Department of Chemistry, Rutgers University, 73 Warren Street, Newark, New Jersey 07102, United States, Email: michal.szostakrutgers.edu

G. Li, P. Lei, M. Szostak, Org. Lett., 2018, 20, 5622-5625.

DOI: 10.1021/acs.orglett.8b02323 (free Supporting Information)


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Abstract

A general, transition-metal-free, and operationally simple method for esterification of amides proceeds under exceedingly mild conditions via a highly selective cleavage of N-C(O) bonds. The reaction offers broad substrate scope and excellent functional group tolerance.

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Key Words

acylation


ID: J54-Y2018