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Regio- and Stereo-Selective Intermolecular Hydroamidation of Ynamides: An Approach to (Z)-Ethene-1,2-Diamides

Zhiyuan Peng, Zhenming Zhang, Yongliang Tu, Xianzhu Zeng, Junfeng Zhao*

*Key Laboratory of Chemical Biology of Jiangxi Province, College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang, 330022 Jiangxi, People's Republic of China, Email: zhaojfjxnu.edu.cn

Z. Peng, Z. Zhang, Y. Tu, X. Zeng, J. Zhao, Org. Lett., 2018, 20, 5688-5691.

DOI: 10.1021/acs.orglett.8b02409



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Abstract

An efficient intermolecular trans-selective β-hydroamidation of ynamides provides (Z)-ethene-1,2-diamide derivatives with excellent regio- and stereo-selectivities for a wide range of substrates. The reaction proceeds under basic conditions in the absence of a transition-metal catalyst.

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Key Words

enamides, sulfonamides


ID: J54-Y2018