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Accessing Polysubstituted Quinazolines via Nickel Catalyzed Acceptorless Dehydrogenative Coupling

Seuli Parua, Rina Sikari, Suman Sinha, Gargi Chakraborty, Rakesh Mondal, Nanda D. Paul*

*Department of Chemistry, Indian Institute of Engineering Science and Technology, Shibpur, Botanic Garden, Howrah 711103, India, Email:

S. Parua, R. Sikari, S. Singha, G. Chakraborty, R. Mondal, N. D. Paul, J. Org. Chem., 2018, 83, 11154-11166.

DOI: 10.1021/acs.joc.8b01479 (free Supporting Information)

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Acceptorless dehydrogenative coupling of 2-aminobenzylamine with benzyl alcohol and 2-aminobenzylalcohol with benzonitrile enables the synthesis of quinazolines. The reactions are catalyzed by cheap and easy to prepare nickel catalysts, containing tetraaza macrocyclic ligands. A wide variety of substituted quinazolines were synthesized in good yields.

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ID: J42-Y2018