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Facile Construction of Hydantoin Scaffolds via a Post-Ugi Cascade Reaction

Zhi-Gang Xu, Yong Ding, Jiang-Ping Meng, Dian-Yong Tang, Yong Li, Jie Lei, Chuan Xu*, Zhong-Zhu Chen*

*University of Electronic Science and Technology of China, Chengdu, Sichuan, 610072; Chongqing University of Arts and Sciences. 319 Honghe Ave., Chongqing 402160, P. R. of China, Email:,

Z.-G. Xu, Y. Ding, J.-P. Meng, D.-Y. Tang, Y. Li, J. Lei, C. Xu, Z.-Z. Chen, Synlett, 2018, 29, 2199-2202.

DOI: 10.1055/s-0037-1610234


An efficient two-step Ugi/cyclization reaction sequence provides hydantoins. This microwave-assisted one-pot cyclization strategy, in which an alkyne group acts as a leaving group under basic conditions, could be applicable to other multicomponent reactions (MCRs) for synthesizing bioactive and drug-like hydantoins.

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proposed mechanism

Key Words

hydantoins, multicomponent reactions, Ugi reaction, alkyne leaving group

ID: J72-Y2018