Facile Construction of Hydantoin Scaffolds via a Post-Ugi Cascade Reaction
Zhi-Gang Xu, Yong Ding, Jiang-Ping Meng, Dian-Yong Tang, Yong Li, Jie Lei, Chuan Xu*, Zhong-Zhu Chen*
*University of Electronic Science and Technology of China,
Chengdu, Sichuan, 610072; Chongqing University of Arts and Sciences. 319 Honghe
Ave., Chongqing 402160, P. R. of China, Email: Xuchuan100
163.com,
18883138277163.com
Z.-G. Xu, Y. Ding, J.-P. Meng, D.-Y. Tang, Y. Li, J. Lei, C. Xu, Z.-Z. Chen, Synlett, 2018, 29, 2199-2202.
DOI: 10.1055/s-0037-1610234
Abstract
An efficient two-step Ugi/cyclization reaction sequence provides hydantoins. This microwave-assisted one-pot cyclization strategy, in which an alkyne group acts as a leaving group under basic conditions, could be applicable to other multicomponent reactions (MCRs) for synthesizing bioactive and drug-like hydantoins.
see article for more examples
proposed mechanism
Key Words
hydantoins, multicomponent reactions, Ugi reaction, alkyne leaving group
ID: J72-Y2018
