Development and Utilization of a Palladium-Catalyzed Dehydration of Primary Amides To Form Nitriles
Mohammed H. Al-Huniti, José Rivera-Chávez, Katsuya L. Colón, Jarrod L. Stanley, Joanna E. Burdette, Cedric J. Pearce, Nicholas H. Oberlies, Mitchell P. Croatt*
*Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, 435 Sullivan Science Building, Greensboro, North Carolina 27402, United States, Email: mpcroattuncg.edu
M. H. Al-Huniti, J. Rivera-Chávez, K. L. Colón, J. L. Stanley, J. E. Burdette, C. J. Pearce, N. H. Oberlies, M. P. Croatt, Org. Lett., 2018, 20, 6046-6050.
A palladium(II)-catalyzed reaction of a broad range of primary amides provides nitriles in the presence of Selectfluor. This efficient and chemoselective reaction tolerates steric bulk and electronic modification.
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