Organic Chemistry Portal



Development and Utilization of a Palladium-Catalyzed Dehydration of Primary Amides To Form Nitriles

Mohammed H. Al-Huniti, José Rivera-Chávez, Katsuya L. Colón, Jarrod L. Stanley, Joanna E. Burdette, Cedric J. Pearce, Nicholas H. Oberlies, Mitchell P. Croatt*

*Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, 435 Sullivan Science Building, Greensboro, North Carolina 27402, United States, Email:

M. H. Al-Huniti, J. Rivera-Chávez, K. L. Colón, J. L. Stanley, J. E. Burdette, C. J. Pearce, N. H. Oberlies, M. P. Croatt, Org. Lett., 2018, 20, 6046-6050.

DOI: 10.1021/acs.orglett.8b02422


A palladium(II)-catalyzed reaction of a broad range of primary amides provides nitriles in the presence of Selectfluor. This efficient and chemoselective reaction tolerates steric bulk and electronic modification.

see article for more examples

Key Words


ID: J54-Y2018