Microwave-Enhanced On-Water Amination of 2-Mercaptobenzoxazoles To Prepare 2-Aminobenzoxazoles
Theeranon Tankam, Jakkrit Srisa, Mongkol Sukwattanasinitt, Sumrit Wacharasindhu*
*Nanotec-CU Center of Excellence on Food and Agriculture, Department of Chemistry, Faculty of Science, Chulalongkorn University Bangkok 10330, Thailand, Email: sumrit.wchula.ac.th
T. Tankam, J. Srisa, M. Sukwattanasinitt, S. Wacharasindhu, J. Org. Chem., 2018, 83, 11936-11943.
DOI: 10.1021/acs.joc.8b01824 (free Supporting Information)
see article for more reactions
A catalyst-free amination of 2-mercaptobenzoxazoles on water under microwave irradiation provides 2-aminobenzoxazoles in good yields via direct amination. Key benefits of this process include an on-water reaction, short reaction time, being scalable and catalyst-free, and use of 2-mercaptobenzoxazoles as an inexpensive starting material.
see article for more examples