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Microwave-Enhanced On-Water Amination of 2-Mercaptobenzoxazoles To Prepare 2-Aminobenzoxazoles

Theeranon Tankam, Jakkrit Srisa, Mongkol Sukwattanasinitt, Sumrit Wacharasindhu*

*Nanotec-CU Center of Excellence on Food and Agriculture, Department of Chemistry, Faculty of Science, Chulalongkorn University Bangkok 10330, Thailand, Email:

T. Tankam, J. Srisa, M. Sukwattanasinitt, S. Wacharasindhu, J. Org. Chem., 2018, 83, 11936-11943.

DOI: 10.1021/acs.joc.8b01824 (free Supporting Information)

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A catalyst-free amination of 2-mercaptobenzoxazoles on water under microwave irradiation provides 2-aminobenzoxazoles in good yields via direct amination. Key benefits of this process include an on-water reaction, short reaction time, being scalable and catalyst-free, and use of 2-mercaptobenzoxazoles as an inexpensive starting material.

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Key Words

benzoxazoles, microwave synthesis

ID: J42-Y2018