A Multicomponent Electrosynthesis of 1,5-Disubstituted and 1-Aryl 1,2,4-Triazoles

Na Yang, Gaoqing Yuan*

*Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, 510640, P. R. China, Email: gqyuanscut.edu.cn

N. Yang, G. Yuan, J. Org. Chem., 2018, 83, 11963-11969.

DOI: 10.1021/acs.joc.8b01808

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Abstract

An electrochemical multicomponent reaction of aryl hydrazines, paraformaldehyde, NH₄OAc, and alcohols provides 1,5-disubstituted and 1-aryl 1,2,4-triazoles. Alcohols act as solvents as well as reactants and NH₄OAc is used as the nitrogen source. With the assistance of reactive iodide radical or I₂ and NH₃ electrogenerated in situ, this process effectively avoids the use of strong oxidants and transition-metal catalysts.

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Key Words

1,2,4-triazoles, electrochemistry, multicomponent reactions

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ID: J42-Y2018