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A Multicomponent Electrosynthesis of 1,5-Disubstituted and 1-Aryl 1,2,4-Triazoles

Na Yang, Gaoqing Yuan*

*Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, 510640, P. R. China, Email: gqyuanscut.edu.cn

N. Yang, G. Yuan, J. Org. Chem., 2018, 83, 11963-11969.

DOI: 10.1021/acs.joc.8b01808 (free Supporting Information)



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Abstract

An electrochemical multicomponent reaction of aryl hydrazines, paraformaldehyde, NH4OAc, and alcohols provides 1,5-disubstituted and 1-aryl 1,2,4-triazoles. Alcohols act as solvents as well as reactants and NH4OAc is used as the nitrogen source. With the assistance of reactive iodide radical or I2 and NH3 electrogenerated in situ, this process effectively avoids the use of strong oxidants and transition-metal catalysts.

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Key Words

1,2,4-triazoles, electrochemistry, multicomponent reactions


ID: J42-Y2018