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A Ferrocene-Based NH-Free Phosphine-Oxazoline Ligand for Iridium-Catalyzed Asymmetric Hydrogenation of Ketones

Yanzhao Wang, Guoqiang Yang, Fang Xie*, Wanbin Zhang*

*School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P. R. China, Email: xiefangsjtu.edu.cn, wanbinsjtu.edu.cn

Y. Wang, G. Yang, F. Xie, W. Zhang, Org. Lett., 2018, 20, 6135-6139.

DOI: 10.1021/acs.orglett.8b02591 (free Supporting Information)


Abstract

An air stable iridium complex of ferrocene-based phosphine-oxazoline ligand exhibits excellent performance for the asymmetric hydrogenation of simple ketones. Exo-α,β-unsaturated cyclic ketones could also be regiospecifically hydrogenated to give chiral allylic alcohols with good results.

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Key Words

reduction of carbonyl compounds, hydrogen


ID: J54-Y2018