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Fe(ClO4)3H2O-Catalyzed Ritter Reaction: A Convenient Synthesis of Amides from Esters and Nitriles

Chengliang Feng*, Bin Yan, Guibo Yin, Junqing Chen, Min Ji

*Institute of Pharmaceutical Engineering, Jiangsu College of Engineering and Technology, Nantong, Jiangsu 226000, P. R. of China, Email:

C. Feng, B. Yan, G. Yin, J. Chen, M. Ji, Synlett, 2018, 29, 2257-2264.

DOI: 10.1055/s-0037-1610658

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Fe(ClO4)3H2O is an economically efficient catalyst for a Ritter reaction under solvent-free conditions. Benzyl, sec-alkyl, and tert-butyl esters reacted with 1, 2, 3 benzyl nitriles and aryl nitriles to provide the corresponding amides in very good yields.

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Key Words

Ritter reaction, Fe(ClO4)3H2O, esters, nitriles, solvent-free reactions

ID: J72-Y2018