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Fe(ClO4)3ĚH2O-Catalyzed Ritter Reaction: A Convenient Synthesis of Amides from Esters and Nitriles

Chengliang Feng*, Bin Yan, Guibo Yin, Junqing Chen, Min Ji

*Institute of Pharmaceutical Engineering, Jiangsu College of Engineering and Technology, Nantong, Jiangsu 226000, P. R. of China, Email: fcl085620163.com

C. Feng, B. Yan, G. Yin, J. Chen, M. Ji, Synlett, 2018, 29, 2257-2264.

DOI: 10.1055/s-0037-1610658 (free Supporting Information)



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Abstract

Fe(ClO4)3ĚH2O is an economically efficient catalyst for a Ritter reaction under solvent-free conditions. Benzyl, sec-alkyl, and tert-butyl esters reacted with 1░, 2░, 3░ benzyl nitriles and aryl nitriles to provide the corresponding amides in very good yields.


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Key Words

Ritter reaction, Fe(ClO4)3ĚH2O, esters, nitriles, solvent-free reactions


ID: J72-Y2018