Fe(ClO₄)₃·H₂O-Catalyzed Ritter Reaction: A Convenient Synthesis of Amides from Esters and Nitriles

Chengliang Feng*, Bin Yan, Guibo Yin, Junqing Chen, Min Ji

*Institute of Pharmaceutical Engineering, Jiangsu College of Engineering and Technology, Nantong, Jiangsu 226000, P. R. of China, Email: fcl085620163.com

C. Feng, B. Yan, G. Yin, J. Chen, M. Ji, Synlett, 2018, 29, 2257-2264.

DOI: 10.1055/s-0037-1610658

---

see article for more reactions

Abstract

Fe(ClO₄)₃·H₂O is an economically efficient catalyst for a Ritter reaction under solvent-free conditions. Benzyl, sec-alkyl, and tert-butyl esters reacted with 1°, 2°, 3° benzyl nitriles and aryl nitriles to provide the corresponding amides in very good yields.

see article for more examples

---

---

Key Words

Ritter reaction, Fe(ClO₄)₃·H₂O, esters, nitriles, solvent-free reactions

---

ID: J72-Y2018