Reductive Deuteration of Nitriles: The Synthesis of α,α-Dideuterio Amines by Sodium-Mediated Electron Transfer Reactions
Yuxuan Ding, Shihui Luo, Adila Adijiang, Hongye Zhao, Jie An*
*College of Science, China Agricultural University, No. 2 Yuanmingyuan West Road, Beijing 100193, China,
Email: jie_an
cau.edu.cn
Y. Ding, S. Luo, A. Adijiang, H. Zhao, J. An, J. Org. Chem., 2018, 83, 12269-12274.
DOI: 10.1021/acs.joc.8b01730
Abstract
A practical and cost-efficient reductive deuteration of nitriles under single-electron transfer conditions enables the synthesis of α,α-dideuterio amines in excellent yields using bench stable and commercially available sodium dispersions and EtOD-d1.
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Key Words
ID: J42-Y2018
