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Reductive Deuteration of Nitriles: The Synthesis of α,α-Dideuterio Amines by Sodium-Mediated Electron Transfer Reactions

Yuxuan Ding, Shihui Luo, Adila Adijiang, Hongye Zhao, Jie An*

*College of Science, China Agricultural University, No. 2 Yuanmingyuan West Road, Beijing 100193, China, Email: jie_ancau.edu.cn

Y. Ding, S. Luo, A. Adijiang, H. Zhao, J. An, J. Org. Chem., 2018, 83, 12269-122274.

DOI: 10.1021/acs.joc.8b01730 (free Supporting Information)


Abstract

A practical and cost-efficient reductive deuteration of nitriles under single-electron transfer conditions enables the synthesis of α,α-dideuterio amines in excellent yields using bench stable and commercially available sodium dispersions and EtOD-d1.

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Key Words

reduction of nitriles, sodium


ID: J42-Y2018