[4-Iodo-3-(isopropylcarbamoyl)phenoxy]acetic Acid as a Highly Reactive and Easily Separable Catalyst for the Oxidative Cleavage of Tetrahydrofuran-2-methanols to γ-Lactones
Takayuki Yakura*, Tomoya Fujiwara, Hideyuki Nishi, Yushi Nishimura, Hisanori Nambu
*Graduate School of Medicine and Pharmaceutical Sciences,
University of Toyama, Sugitani, Toyama 930-0194, Japan, Email: yakura
pha.u-toyama.ac.jp
T. Yakura, T. Fujiwara, H. Nishi, Y. Nishimura, H. Nambu, Synlett, 2018, 29, 2316-2320.
DOI: 10.1055/s-0037-1610657
Abstract
[4-Iodo-3-(isopropylcarbamoyl)phenoxy]acetic acid is a highly reactive and easily separable catalyst for the oxidative cleavage of tetrahydrofuran-2-methanols to γ-lactones in the presence of Oxone as the terminal oxidant.The catalyst and product were easily separated by only liquid-liquid separation without chromatography.
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Key Words
hypervalent iodine compounds, iodobenzamide, lactones, organocatalysis, oxidative cleavage, Oxone
ID: J72-Y2018
