Fluorine as a Traceless Directing Group for the Regiodivergent Synthesis of Indoles and Tryptophans
Anna Andries-Ulmer, Christoph Brunner, Julia Rehbein*, Tanja Gulder*
*Institute of Organic Chemistry, University of Regensburg,
93053 Regensburg; Department of Chemistry, Technical University of Munich, 85748 Garching, Germany,
Email: julia.rehbein
ur.de, tanja.guldertum.de
A. Andries-Ulmer, C. Brunner, J. Rehbein, T. Gulder, J. Am. Chem. Soc., 2018, 140, 13034-13041.
DOI: 10.1021/jacs.8b08350
see article for more reactions
Abstract
The use of a hypervalent F-iodane enables a regiodivergent synthesis of indoles and tryptophans from styrenes via a spirocyclic F-cyclopropane as the common intermediate.
see article for more examples
chemodivergent transformations of styrenes using F-iodane 4
Key Words
ID: J48-Y2018
