Iron-Catalyzed Enantioselective Si-H Bond Insertions
Haorui Gu, Zhao Han, Hujun Xie*, Xufeng Lin*
*Department of Applied Chemistry, Zhejiang Gongshang University, Hangzhou 310018; Department of Chemistry, Zhejiang University, Hangzhou 310027, China,
Email: hujunxie
gmail.com, lxfokzju.edu.cn
H. Gu, Z. Han, H. Xie, X. Lin, Org. Lett., 2018, 20, 6544-6549.
DOI: 10.1021/acs.orglett.8b02868
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Abstract
A chiral spiro-bisoxazoline ligand has proven to be an optimal ligand for an asymmetric iron-catalyzed enantioselective Si-H bond insertion reaction of α-diazoesters to provide chiral α-silyl esters in good yields with high enantioselectivities. The reaction proceeds via a concerted quintet transition state.
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Key Words
ID: J54-Y2018
