A Highly Efficient NHC-Catalyzed Aerobic Oxidation of Aldehydes to Carboxylic Acids
Anil Kumar Khatana, Vikram Singh, Manoj Kumar Gupta, Bhoopendra Tiwari*
*Division of Molecular Synthesis & Drug Discovery, Centre of Biomedical Research, SGPGIMS-Campus, Raebareli Road, Lucknow-226014, India, Email: btiwaricbmr.res.in
A. K. Khatana, V. Singh, M. K. Gupta, B. Tiwari, Synthesis, 2018, 50, 4290-4294.
DOI: 10.1055/s-0037-1610069 (free Supporting Information)
An N-heterocyclic carbene (NHC) organocatalytic aerobic oxidation of aldehydes provides the corresponding carboxylic acids under mild reaction conditions. Remarkably, this method enables an efficient conversion of different classes of aldehydes including highly challenging electron-rich aryl aldehydes, ortho-substituted aryl aldehydes, various heteroaromatic aldehydes and α,β-unsaturated aldehydes.
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