A Highly Efficient NHC-Catalyzed Aerobic Oxidation of Aldehydes to Carboxylic Acids
Anil Kumar Khatana, Vikram Singh, Manoj Kumar Gupta, Bhoopendra Tiwari*
*Division of Molecular Synthesis & Drug Discovery, Centre of
Biomedical Research, SGPGIMS-Campus, Raebareli Road, Lucknow-226014, India, Email:
btiwari
cbmr.res.in
A. K. Khatana, V. Singh, M. K. Gupta, B. Tiwari, Synthesis, 2018, 50, 4290-4294.
DOI: 10.1055/s-0037-1610069
Abstract
An N-heterocyclic carbene (NHC) organocatalytic aerobic oxidation of aldehydes provides the corresponding carboxylic acids under mild reaction conditions. Remarkably, this method enables an efficient conversion of different classes of aldehydes including highly challenging electron-rich aryl aldehydes, ortho-substituted aryl aldehydes, various heteroaromatic aldehydes and α,β-unsaturated aldehydes.
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Key Words
carboxylic acids, aldehydes, N-heterocyclic carbenes, aerobic oxidation, organocatalysis
ID: J66-Y2018
