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Metal-Free Three-Component Oxyalkynylation of Alkenes

Yangshan Li, Ran Lu, Shutao Sun, Lei Liu*

*School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China, Email: leiliusdu.edu.cn

Y. Li, R. Lu, S. Sun, L. Liu, Org. Lett., 2018, 20, 6836-6839.

DOI: 10.1021/acs.orglett.8b02954 (free Supporting Information)


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Abstract

(NH4)2S2O8 mediates a metal-free three-component alkene oxyalkynylation using H2O or alcohol as oxygenation agent. The reversed regioselectivity should be dictated by an alkene radical cation intermediate.

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Key Words

alkynylation, hydroxylation, ammonium peroxydisulfate, multicomponent reactions


ID: J54-Y2018