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A Method for Synthesis of 3-Hydroxy-1-indanones via Cu-Catalyzed Intramolecular Annulation Reactions

Guoxue He, Chenglin Wu, Jianhui Zhou, Qiaolan Yang, Chunmei Zhang, Yu Zhou, Huabei Zhang, Hong Liu*

*State Key Laboratory of Drug Research and Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China, Email:

G. He, C. Wu, J. Zhou, Q. Yang, C. Zhang, Y. Zhou, H. Zhang, H. Liu, J. Org. Chem., 2018, 83, 13356-13362.

DOI: 10.1021/acs.joc.8b02149 (free Supporting Information)

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A facile and highly efficient copper-catalyzed intramolecular annulation of simple 2-ethynylbenzaldehyde derivatives provides 3-hydroxy-1-indanones under mild conditions in very good yields.

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Key Words


ID: J42-Y2018